BAY AREA PHARMACOKINETIC AND PHARMACODYNAMICS (BAPKPD) NETWORK
invites you to a webinar on
Thursday, June 10th, 2021
12:00-1:00 PM PDT
by
Kathy Giacomini, Ph.D.
Professor,
Department of Bioengineering and Therapeutic Sciences
UCSF Schools of Pharmacy and Medicine
Special Topics Webinar:
High Throughput Screening and Real World Biomarkers to Predict Drug-Drug and Drug-Nutrient Interactions:
Implications to polypharmacy associated with COVID treatment
Individuals with serious COVID infections often have pre-existing co-morbidities and are generally older. Thus, in addition to being prescribed drugs for the treatment of COVID19 and its sequelae, many of these individuals are taking a myriad of other drugs. In this presentation, I will describe a screening study of 25 small molecule drugs in clinical trials for COVID19 against 11 drug transporters, which are targets for clinically relevant drug-drug interactions (DDIs). Our in vitro studies revealed that 20 of the 25 drugs met the criteria suggested by FDA DDI guidances to consider a clinical DDI study. Further, I will describe the analyses of real-world transporter biomarkers in data from electronic health records, which suggested that several of the drugs actually do cause transporter-mediated DDIs clinically. I will end with a discussion of the propensity for many anti-microbial drugs to perpetrate clinical DDIs and drug-nutrient interactions, and the use of various biomarkers for predicting DDIs in pre- and post-marketing settings.
Register:
https://tinyurl.com/BAPKPD-webinar2021For questions about the event, contact Rebecca Braille at rbaillie@rosaandco.com
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